Basic information of Tgfb1 :
| Official Symbol of Gene | Tgfb1 |
| Species | Mus musculus |
| Entrez Gene ID | 21803 |
| Official Full Name | transforming growth factor, beta 1 |
| Also known as | Tgfb; Tgfb-1; TGFbeta1; TGF-beta1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000002603 AllianceGenome:MGI:98725 |
| Map Location | 7 A3; 7 13.98 cM |
| Drug | sodium benzoate (NaB) |
| Interaction Type | activator |
Sample information of multiple sclerosis:
| Descent | PLP139–151-specific 5B6 TCR Tg mice |
| Disease | experimental autoimmune encephalomyelitis |
Literature information of multiple sclerosis :
| Pubmed ID | 27605008 |
| Year | 2017 |
| Title | Sodium benzoate, a food additive and a metabolite of cinnamon, enriches regulatory T cells via STAT6-mediated upregulation of TGFβ |
Results of multiple sclerosis :
| Result | These studies identify a new function of NaB in upregulating TGFβ via activation of STAT6, which may be beneficial in MS patients. |
| Mechanism/pathway | Here, we demonstrated that NaB induced the expression of TGFβ mRNA and protein in normal as well as proteolipid protein-primed splenocytes. Presence of a consensus STAT6-binding site in the promoter of TGFβ gene, activation of STAT6 in splenocytes by NaB, recruitment of STAT6 to the TGFβ promoter by NaB, and abrogation of NaB-induced expression of TGFβ in splenocytes by siRNA knockdown of STAT6 suggest that NaB induces the expression of TGFβ via activation of STAT6. |
