Basic information of CXCL10 :
| Official Symbol of Gene | CXCL10 |
| Species | Homo sapiens |
| Entrez Gene ID | 3627 |
| Official Full Name | C-X-C motif chemokine ligand 10 |
| Also known as | C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000169245 MIM:147310; AllianceGenome:HGNC:10637 |
| Map Location | 4q21.1 |
| Drug | a combination of both phytocannabinoids (1:1 ratio, 10:10 μM) |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | NA |
| Disease | MS |
Literature information of multiple sclerosis :
| Pubmed ID | 35335126 |
| Year | 2022 |
| Title | Botanically-Derived etrahydrocannabinol and Cannabidiol,and Their 1:1 Combination, Modulate T oll-like Receptor 3 and 4 Signalling in Immune Cells from People with Multiple Sclerosis |
Results of multiple sclerosis :
| Result | THC and CBD (delivered in 1:1 combination at 10 μM) attenuated TLR3-induced CXCL10 and IFN-β protein expression in PBMCs from pwMS and HCs, and this effect was not seen consistently when THC and CBD were delivered alone. |
| Mechanism/pathway | The innate immune response to bacterial and viral molecules involves the coordinated production of cytokines, chemokines, and type I interferons (IFNs), which is orchestrated by toll-like receptors (TLRs) |
