Basic information of IFNB1 :
| Official Symbol of Gene | IFNB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3456 |
| Official Full Name | interferon beta 1 |
| Also known as | IFB; IFF; IFNB; IFN-beta |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000171855 MIM:147640; AllianceGenome:HGNC:5434 |
| Map Location | 9p21.3 |
| Drug | a combination of both phytocannabinoids (1:1 ratio, 10:10 μM) |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | NA |
| Disease | MS |
Literature information of multiple sclerosis :
| Pubmed ID | 35335126 |
| Year | 2022 |
| Title | Botanically-Derived etrahydrocannabinol and Cannabidiol,and Their 1:1 Combination, Modulate T oll-like Receptor 3 and 4 Signalling in Immune Cells from People with Multiple Sclerosis |
Results of multiple sclerosis :
| Result | THC and CBD (delivered in 1:1 combination at 10 μM) attenuated TLR3-induced CXCL10 and IFN-β protein expression in PBMCs from pwMS and HCs, and this effect was not seen consistently when THC and CBD were delivered alone. |
| Mechanism/pathway | The innate immune response to bacterial and viral molecules involves the coordinated production of cytokines, chemokines, and type I interferons (IFNs), which is orchestrated by toll-like receptors (TLRs) |
