Basic information of TNF :
| Official Symbol of Gene | TNF |
| Species | Homo sapiens |
| Entrez Gene ID | 7124 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892 |
| Map Location | 6p21.33 |
| Drug | a combination of both phytocannabinoids (1:1 ratio, 10:10 μM) |
| Interaction Type | activator |
Sample information of multiple sclerosis:
| Descent | NA |
| Disease | MS |
Literature information of multiple sclerosis :
| Pubmed ID | 35335126 |
| Year | 2022 |
| Title | Botanically-Derived etrahydrocannabinol and Cannabidiol,and Their 1:1 Combination, Modulate T oll-like Receptor 3 and 4 Signalling in Immune Cells from People with Multiple Sclerosis |
Results of multiple sclerosis :
| Result | In terms of LPS, TLR4 activation promoted TNF-α expression in PBMCs from both cohorts, and, interestingly , CBD when delivered alone at 10 μM, and in combination with THC (in 1:1 combination at 10 μM), exacerbated TLR4-induced TNF-α protein expression in PBMCs from pwMS and HCs. |
| Mechanism/pathway | The aim of this study was to assess the impact of THC and CBD, when delivered in isolation and in combination (1:1), on TLR3- and TLR4-dependent signalling in peripheral blood mononuclear cells (PBMCs) from people with MS (pwMS; n = 21) and healthy controls (HCs; n = 26). |
