Basic information of Act1 :
| Official Symbol of Gene | Act1 |
| Species | Mus musculus |
| Entrez Gene ID | 109776 |
| Official Full Name | actin related gene 1 |
| Also known as | Act-1 |
| Gene Type | protein coding |
| dbXrefs | MGI:MGI:87897 |
| Map Location | chromosome: 5 |
| Drug | SRSF10 |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | C57Bl/6J |
| Disease | experimental autoimmune encephalomyelitis |
Literature information of multiple sclerosis :
| Pubmed ID | 33941656 |
| Year | 2021 |
| Title | Regulator of IL-17 Signaling through the SRSF10?IRF1?Act1 Axis in Autoimmune Diseases |
Results of multiple sclerosis :
| Result | These findings suggest that TRAF3IP2-AS1 and/or SRSF10 may represent attractive therapeutic targets in the treatment of IL-17?related autoimmune diseases, such as psoriasis and multiple sclerosis. |
| Mechanism/pathway | IL-17A plays an essential role in the pathogenesis of many autoimmune diseases, including psoriasis and multiple sclerosis. Act1 is a critical adaptor in the IL-17A signaling pathway. |
