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Basic information of Rhoa :

Official Symbol of Gene Rhoa
Species Mus musculus
Entrez Gene ID 11848
Official Full Name ras homolog family member A
Also known as ras homolog family member A
Gene Type protein coding
dbXrefs Ensembl:ENSMUSG00000007815 AllianceGenome:MGI:1096342
Map Location 9; 9 F2
Drug Fingolimod
Interaction Type activator

Sample information of multiple sclerosis:

Descent C57Bl/6J
Disease experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID 26980486
Year 2016
Title The multiple sclerosis drug fingolimod (FTY720) stimulates neuronal gene expression, axonal growth and regeneration

Results of multiple sclerosis :

Result In summary, we uncovered a broader cellular and therapeutic operation mode of FTY720, suggesting beneficial FTY720 effects also on CNS neurons during MS therapy and for treatment of other neurodegenerative diseases FTY720 effects also on CNS neurons during MS therapy and for treatment of other neurodegenerative diseases
Mechanism/pathway Fingolimod (FTY720) is a new generation oral treatment for multiple sclerosis (MS). So far, FTY720 was mainly considered to target trafficking of immune cells but not brain cells such as neurons.