Basic information of INPP5D :
| Official Symbol of Gene | INPP5D |
| Species | Homo sapiens |
| Entrez Gene ID | 3635 |
| Official Full Name | inositol polyphosphate-5-phosphatase D |
| Also known as | SHIP; SHIP1; SHIP-1; hp51CN; SIP-145; p150Ship |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000168918 MIM:601582; AllianceGenome:HGNC:6079 |
| Map Location | 2q37.1 |
| Drug | Mannuronic Acid |
| Interaction Type | activator |
Sample information of multiple sclerosis:
| Descent | NA |
| Disease | SPMS |
Literature information of multiple sclerosis :
| Pubmed ID | 33908653 |
| Year | 2021 |
| Title | Evaluation of the Effect of Mannuronic Acid as a Novel NSAID with Immunosuppressive Properties on Expression of SOCS1, SOCS3, SHIP1 and TRAF6 Genes and Serum Level of IL-6 and TNF-α in Patients with Multiple Sclerosis |
Results of multiple sclerosis :
| Result | The gene expression of SOCS1, SOCS3, TRAF6 and SHIP1 were measured at the baseline and after 6 months of therapy with M2000, by using quantitative real-time PCR method. |
| Mechanism/pathway | The efficacy and safety of β-D-Mannuronic acid (M2000) as a novel immunosuppressive drug, patented (PCT/EP2017/067920), has been shown in experimental model of MS and also in a phase II clinical trial. |
