Basic information of Itga4 :

Official Symbol of Gene	Itga4
Species	Mus musculus
Entrez Gene ID	16401
Official Full Name	integrin alpha 4
Also known as	CD49D; Itga4B
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000027009 AllianceGenome:MGI:96603
Map Location	2 C3; 2 47.38 cM
Drug	natalizumab
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57Bl/6J
Disease	experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID	19179279
Year	2009
Title	β1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity

Results of multiple sclerosis :

Result	Collectively, these results suggest that the pri-mary action of natalizumab is interference with T cell extravasation via inhibition of α4β1 integrins.
Mechanism/pathway	inhibiting the α4 subunit of the integrin heterodimers α4β1 and α4β7 with the monoclonal antibody natalizumab is an effective treatment for multiple sclerosis (MS).