Basic information of Alox5 :

Official Symbol of Gene	Alox5
Species	Mus musculus
Entrez Gene ID	11689
Official Full Name	arachidonate 5-lipoxygenase
Also known as	5LO; 5LX; 5-LO; 5-LOX; F730011J02
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000025701 AllianceGenome:MGI:87999
Map Location	6 E3; 6 53.79 cM
Drug	MK886
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57Bl/6J
Disease	experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID	21555210
Year	2011
Title	Inhibition of 5-lipoxygenase activity in mice during cuprizone-induced demyelination attenuates neuroinflammation, motor dysfunction and axonal damage

Results of multiple sclerosis :

Result	Thus, 5-LO inhibition may be a useful therapeutic treatment in demyelinating diseases of the CNS
Mechanism/pathway	Increased expression of 5-lipoxygenase (5-LO), a key enzyme in the biosynthesis of leukotrienes (LTs), has been reported in MS lesions and LT levels are elevated in the cerebrospinal fluid of MS patients.