Basic information of Itga4 :

Official Symbol of Gene	Itga4
Species	Mus musculus
Entrez Gene ID	16401
Official Full Name	integrin alpha 4
Also known as	CD49D; Itga4B
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000027009 AllianceGenome:MGI:96603
Map Location	2 C3; 2 47.38 cM
Drug	antisense oligonucleotides(ASO)
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57Bl/6J
Disease	experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID	31506448
Year	2019
Title	Reduction of integrin alpha 4 activity through splice modulating antisense oligonucleotides

Results of multiple sclerosis :

Result	With the promising results in ameliorating disease progression, we are optimistic that the candidate oligomer may also be applicable to many other diseases associated with integrin alpha 4 mediated inflammation.
Mechanism/pathway	This highly specific strategy to down-regulate protein expression through interfering with normal exon selection during pre-mRNA processing should be applicable to many other gene targets that undergo splicing during expression