Basic information of Rtn4 :

Official Symbol of Gene	Rtn4
Species	Mus musculus
Entrez Gene ID	68585
Official Full Name	reticulon 4
Also known as	ASY; NgA; NOGO; NSP-CL; Nogo-A; Nogo-B; Nogo-C; mKIAA0886; mKIAA4153; 1110020G17Rik; C130026I10Rik
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000020458 AllianceGenome:MGI:1915835
Map Location	11; 11 A3.3
Drug	Bu Shen Yi sui capsule（BSYSC)
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57Bl/6J
Disease	experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID	28668079
Year	2017
Title	Effects of Bu Shen Yi sui capsule on NogoA/NgR and its signaling pathways RhoA/ROCK in mice with experimental autoimmune encephalomyelitis

Results of multiple sclerosis :

Result	BSYSC could attenuate axonal injury and promote repair of axonal damage in EAE mice in part through the down-regulation of NogoA/NgR and RhoA/ROCK signaling pathways.
Mechanism/pathway	Axon growth inhibitory factors NogoA/Nogo receptor (NgR) and its signaling pathways RhoA/Rho kinase (ROCK) play a critical role in the repair of nerve damage in multiple sclerosis (MS). Bu Shen Yi Sui Capsule (BSYSC) is an effective Chinese formula utilized to treat MS in clinical setting and noted for its potent neuroprotective effects.