Basic information of Gper1 :

Official Symbol of Gene	Gper1
Species	Mus musculus
Entrez Gene ID	76854
Official Full Name	G protein-coupled estrogen receptor 1
Also known as	Gper; Ceprl; FEG-1; Gpr30; CMKRL2; GPCR-Br; 6330420K13Rik
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000053647 AllianceGenome:MGI:1924104
Map Location	5; 5 G2
Drug	G-1
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	C57Bl/6J
Disease	experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID	19234228
Year	2009
Title	Membrane Estrogen Receptor Regulates EAE Through Upregulation of Programmed Death 1

Results of multiple sclerosis :

Result	This study is the first to evaluate the protective effect of GPR30 activation on EAE, and provides a strong foundation for the clinical application of GPR30 agonists such as G-1 in MS.
Mechanism/pathway	Treatment with G-1, an agonist that selectively activates GPR30 without engagement of the iERs, retained estradiol's ability to protect against clinical and histological EAE without estradiol-associated side effects, deviated cytokine profiles and enhanced suppressive activity of CD4+Foxp3+ Treg cells through a GPR30- and programmed death 1 (PD-1)-dependent mechanism