Basic information of Adh5 :

Official Symbol of Gene	Adh5
Species	Mus musculus
Entrez Gene ID	11532
Official Full Name	alcohol dehydrogenase 5 (class III), chi polypeptide
Also known as	Adh3; Adh-5; GSNOR
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000028138 AllianceGenome:MGI:87929
Map Location	3; 3 G3
Drug	N6022
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	C57Bl/6J
Disease	experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID	34175668
Year	2021
Title	Regulation of B cell functions by S-nitrosoglutathione in the EAE model

Results of multiple sclerosis :

Result	The data presented here provide evidence of the role of GSNO in shifting B cell immune balance (IL-10 >IL-6) and the preclinical relevance of N6022, a first-in-class drug targeting GSNOR with proven human safety, as therapeutics for autoimmune disorders including multiple sclerosis.
Mechanism/pathway	the GSNO/N6022-mediated regu-lation of IL-10 vs. IL-6 was not limited to regulatory B cells but also to a broad range of B cell subsets and antibody-secreting cells.