Basic information of Vegf :

Official Symbol of Gene	Vegf
Species	Mus musculus
Entrez Gene ID	22339
Official Full Name	vascular endothelial growth factor A
Also known as	Vpf; Vegf
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000023951 AllianceGenome:MGI:103178
Map Location	17 C; 17 22.79 cM
Drug	Adenoviral delivery of soluble VEGF receptor 1 (sFlt-1)
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57Bl/6J
Disease	experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID	18721816
Year	2008
Title	Adenoviral delivery of soluble VEGF receptor 1 (sFlt-1) inhibits experimental autoimmune encephalomyelitis in dark Agouti (DA) rats

Results of multiple sclerosis :

Result	This study demonstrates that sFlt-1(1-3) gene transfer into the brain ameliorates the severity of EAE by inhibiting monocyte recruitment in the CNS of dark Agouti rats.
Mechanism/pathway	Previous studies have shown that vascular endothelial growth factor (VEGF) expression is up-regulated in both multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), a model for MS, and may exacerbate the disease.