Basic information of Rorc :
| Official Symbol of Gene | Rorc |
| Species | Mus musculus |
| Entrez Gene ID | 19885 |
| Official Full Name | RAR-related orphan receptor gamma |
| Also known as | TOR; Thor; Nr1f3; RORgamma |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000028150 AllianceGenome:MGI:104856 |
| Map Location | 3; 3 F2.1 |
| Drug | RORγT inhibitors. |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | C57Bl/6J |
| Disease | experimental autoimmune encephalomyelitis |
Literature information of multiple sclerosis :
| Pubmed ID | 28009290 |
| Year | 2016 |
| Title | Inhibition of RORgT Skews TCRa Gene Rearrangement and Limits T Cell Repertoire Diversity |
Results of multiple sclerosis :
| Result | Guo et al. find that small-molecule RORgT antagonist treatment induces CD4+CD8+ thymocyte apoptosis, skews the T cell repertoire, prevents autoreactive T cell development, and delays autoimmune EAE progression. |
| Mechanism/pathway | Thus, targeting RORgT not only inhibits Th17 cell development and function but also fundamentally alters thymic-emigrant recognition of self and foreign antigens.The analysis of RORg inhibitors has allowed us to gain a broader perspective of the diverse function of RORgT and its impact on T cell biology |
