Basic information of Mir20a :
| Official Symbol of Gene | Mir20a |
| Species | Mus musculus |
| Entrez Gene ID | 387139 |
| Official Full Name | Mir-20; Mirn20; Mirn20a; mir-20a; mmu-mir-20a |
| Also known as | Mir-20; Mirn20; Mirn20a; mir-20a; mmu-mir-20a |
| Gene Type | ncRNA |
| dbXrefs | Ensembl:ENSMUSG00000065442 miRBase:MI0000568; AllianceGenome:MGI:2676872 |
| Map Location | 14 E4; 14 |
| Drug | miR-20a antagomirs |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | C57Bl/6J |
| Disease | experimental autoimmune encephalomyelitis |
Literature information of multiple sclerosis :
| Pubmed ID | 34039371 |
| Year | 2021 |
| Title | miR-20a suppresses Treg differentiation by targeting Map3k9 in experimental autoimmune encephalomyelitis |
Results of multiple sclerosis :
| Result | miR-20a suppresses the differentiation of antigen-specific CD4+ T cells into Tregs in EAE by decreasing the expression of Map3k9. miR-20a antagomirs alleviate EAE, suggesting a new therapy for EAE and CNS inflammatory demyelinating diseases. |
| Mechanism/pathway | Experimental autoimmune encephalomyelitis (EAE) is a model for inflammatory demyelinating dis-eases of the central nervous system (CNS), a group of autoimmune diseases characterized by inflammatory infiltra-tion, demyelination, and axonal damage. miR-20a is dysregulated in patients with CNS inflammatory demyelinating diseases; however, the function of miR-20a remains unclear. In this study, we intended to explore the role of miR-20a in EAE. |
