Basic information of Rorc :
| Official Symbol of Gene | Rorc |
| Species | Mus musculus |
| Entrez Gene ID | 19885 |
| Official Full Name | RAR-related orphan receptor gamma |
| Also known as | TOR; Thor; Nr1f3; RORgamma |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000028150 AllianceGenome:MGI:104856 |
| Map Location | 3; 3 F2.1 |
| Drug | DDC |
| Interaction Type | activator |
Sample information of multiple sclerosis:
| Descent | C57Bl/6J |
| Disease | experimental autoimmune encephalomyelitis |
Literature information of multiple sclerosis :
| Pubmed ID | 35453073 |
| Year | 2022 |
| Title | 2', 4'-Dihydroxy-2,3-dimethoxychalcone: A pharmacological inverse agonist of RORγt ameliorating Th17-driven inflammatory diseases by regulating Th17/Treg. |
Results of multiple sclerosis :
| Result | In conclusion, our study provides a scientific basis that DDC, as an inverse agonist of RORγt with simple structure, rich sources, low cost, high efficiency, and low toxicity, has great potential for the development of a novel effective immunomodulator for the treatment of Th17-mediated inflammatory diseases. |
| Mechanism/pathway | Multiple sclerosis, inflammatory bowel disease and organ transplant rejection are related to Th17 cell development and inflammatory respond. RORγt, a specific transcription factor regulating Th17 cell differentiation, is a pivotal target for the treatment of diseases. |
