Basic information of CXCL10 :

Official Symbol of Gene	CXCL10
Species	Homo sapiens
Entrez Gene ID	3627
Official Full Name	C-X-C motif chemokine ligand 10
Also known as	C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000169245 MIM:147310; AllianceGenome:HGNC:10637
Map Location	4q21.1
Drug	AS-POcrg2
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	MS
Disease	MS

Literature information of multiple sclerosis :

Pubmed ID	8764376
Year	1996
Title	Chronic intrathecal infusion of phosphorothioate or phosphodiester antisense oligonucleotides against cytokine responsive gene-2/IP-10 in experimental allergic encephalomyelitis of lewis rat

Results of multiple sclerosis :

Result	The antisense treatment did not alter inflammation of the spinal cord. While AS-PS oligonucleotides were unsuitable for intrathecal administration, AS-POcrg2 were not toxic and reduced paralysis due to EAE.
Mechanism/pathway	The role of CRG-2 protein (murine IP-10) in experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis, was tested by blocking crg-2 mRNA synthesis using chronic infusion of antisense oligonucleotides into lumbar subarachnoid space by osmotic minipumps.