Basic information of Yap1 :
| Official Symbol of Gene | Yap1 |
| Species | Mus musculus |
| Entrez Gene ID | 22601 |
| Official Full Name | yes-associated protein 1 |
| Also known as | Yap; Yki; Yap65; Yorkie |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000053110 AllianceGenome:MGI:103262 |
| Map Location | 9; 9 A1 |
| Drug | XMU-MP-1 |
| Interaction Type | activator |
Sample information of multiple sclerosis:
| Descent | C57Bl/6J |
| Disease | experimental autoimmune encephalomyelitis |
Literature information of multiple sclerosis :
| Pubmed ID | 34373754 |
| Year | 2021 |
| Title | Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling |
Results of multiple sclerosis :
| Result | activation of YAP signaling by XMU-MP-1 relieved the neuroinflammation and demyelination in optic nerve of EAE mice. |
| Mechanism/pathway | Taken together, these results indicated that activation of YAP signaling by XMU-MP-1 could reduce inflammatory infiltration and demyelination and the loss of RGCs in EAE mice through upregulating the TGF-β signaling. |
