Basic information of Ggt1 :

Official Symbol of Gene	Ggt1
Species	Mus musculus
Entrez Gene ID	14598
Official Full Name	gamma-glutamyltransferase 1
Also known as	GGT; dwg; Ggtp; CD224; GGT 1; GGT-1
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000006345 AllianceGenome:MGI:95706
Map Location	10; 10 C1
Drug	Acivicin
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57Bl/6J
Disease	experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID	32284594
Year	2020
Title	Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation

Results of multiple sclerosis :

Result	identified the glutathione regulating compound acivicin with potent therapeutic effects in chronic and relapsing multiple sclerosis (MS) models
Mechanism/pathway	By GGT activity assay and quantitative real-time cell imaging of intracellular glutathione37, we showed that fibrin increased GGT activity and induced degradation of glutathione (Fig. 6b, c and Extended Data Fig. 6a,b). Acivicin and GGsTop restored glutathione levels in fibrin-treated macrophages and decreased ROS production