Basic information of Ido1 :

Official Symbol of Gene	Ido1
Species	Mus musculus
Entrez Gene ID	15930
Official Full Name	indoleamine 2,3-dioxygenase 1
Also known as	Ido; Indo
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000031551 AllianceGenome:MGI:96416
Map Location	8; 8 A2
Drug	INCB024360
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57Bl/6J
Disease	experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID	33040279
Year	2020
Title	Involvement of Indoleamine-2,3-Dioxygenase and Kynurenine Pathway in Experimental Autoimmune Encephalomyelitis in Mice

Results of multiple sclerosis :

Result	The administration of IDO inhibitor (INCB024360) was able to alleviate weight loss, clinical signs and blunting inflammatory process, suggesting that the increase in IDO/KMO activity and mRNA levels are involved in the severity of the clinical course of EAE.
Mechanism/pathway	Evidence has suggested that the activation of indoleamine-2,3-dioxygenase (IDO), the rate-limiting enzyme in the kynurenine pathway (KP), plays a crucial role in inflammation-related diseases.