Basic information of Il-12 a :
| Official Symbol of Gene | Il-12 a |
| Species | Mus musculus |
| Entrez Gene ID | 16159 |
| Official Full Name | interleukin 12a |
| Also known as | p35; Ll12a; Il-12a; IL-12p35 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000027776 AllianceGenome:MGI:96539 |
| Map Location | 3 E1; 3 31.92 cM |
| Drug | DMF, dimethylfumarate |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | C57Bl/6J |
| Disease | experimental autoimmune encephalomyelitis |
Literature information of multiple sclerosis :
| Pubmed ID | 21987655 |
| Year | 2011 |
| Title | Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells |
Results of multiple sclerosis :
| Result | This therapeutic approach improves Th1- and Th17-mediated autoimmune diseases such as psoriasis and MS by interfering with IL-12 and IL-23 production. |
| Mechanism/pathway | Type II DCs result from fumarate- induced glutathione (GSH) depletion, followed by increased hemoxygenase-1 (HO-1) expression and impaired STAT1 phosphorylation. Induced HO-1 is cleaved, whereupon the N-terminal fragment of HO-1 translocates into the nucleus and interacts with AP-1 and NF-î«B sites of the IL-23p19 promoter. This interaction prevents IL-23p19 transcription without affecting IL-12p35, whereas STAT1 inactivation prevents IL-12p35 transcription without affecting IL-23p19. |
