Basic information of C3 :

Official Symbol of Gene	C3
Species	Mus musculus
Entrez Gene ID	12266
Official Full Name	complement component 3
Also known as	17 D; 17 29.72 cM
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000024164 AllianceGenome:MGI:88227
Map Location	17 D; 17 29.72 cM
Drug	AA v - crry
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57Bl/6J
Disease	experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID	31883839
Year	2020
Title	Targeted complement inhibition at synapses prevents microglial synaptic engulfment and synapse loss in demyelinating disease

Results of multiple sclerosis :

Result	AA V-Crry treatment significantly blocked loss of visual acuity in mice at both the onset and peak of EAE.
Mechanism/pathway	Viral overexpression of the complement inhibitor Crry at C3-bound synapses decreased microglial engulfment of synapses and protected visual function.