Basic information of Cntf :
| Official Symbol of Gene | Cntf |
| Species | Mus musculus |
| Entrez Gene ID | 12803 |
| Official Full Name | ciliary neurotrophic factor |
| Also known as | NA |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000079415 AllianceGenome:MGI:88439 |
| Map Location | 19 A; 19 8.73 cM |
| Drug | ursolic acid |
| Interaction Type | activator |
Sample information of multiple sclerosis:
| Descent | C57Bl/6J |
| Disease | experimental autoimmune encephalomyelitis |
Literature information of multiple sclerosis :
| Pubmed ID | 32253301 |
| Year | 2020 |
| Title | A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination |
Results of multiple sclerosis :
| Result | Oral treatment with UA significantly decreased disease severity and CNS inflammation and demyelination in experimental autoimmune encephalomyelitis (EAE), an animal model of MS. |
| Mechanism/pathway | Mechanistically, UA induced promyelinating neurotrophic factor CNTF in astrocytes by peroxisome proliferator-activated receptor γ(PPARγ)/CREB signaling, as well as by up-regulation of myelin-related gene expression during oligodendrocyte maturation via PPARγ activation. |
