Basic information of Il21 :

Official Symbol of Gene	Il21
Species	Mus musculus
Entrez Gene ID	60505
Official Full Name	interleukin 21
Also known as	IL-21
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000027718 AllianceGenome:MGI:1890474
Map Location	3; 3 B
Drug	AAV8.sIL21R
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57Bl/6J
Disease	experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID	35902536
Year	2022
Title	Therapeutic Effect of IL-21 Blockage by Gene Therapy in Experimental Autoimmune Encephalomyelitis

Results of multiple sclerosis :

Result

Although the administration of the treatment during the development of the immune response was counterproductive, the preventive administration of the therapeutic vectors showed a protective effect by reducing the number of animals that developed the disease, as well as an improvement at the histopathological level and a modification of the immunological profile of the animals treated with the AAV8.sIL21R.

Mechanism/pathway

The pathogenic role of the interleukin 21 (IL-21) in different autoimmune diseases, such as multiple sclerosis (MS), has been extensively studied.