Basic information of Mapk3 :

Official Symbol of Gene	Mapk3
Species	Mus musculus
Entrez Gene ID	26417
Official Full Name	mitogen-activated protein kinase 3
Also known as	p44; Erk1; Ert2; Mnk1; Erk-1; Esrk1; Prkm3; Mtap2k; p44erk1; p44mapk
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000063065 AllianceGenome:MGI:1346859
Map Location	7 F3; 7 69.25 cM
Drug	tyrphostin A9
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	C57Bl/6J
Disease	experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID	35143827
Year	2022
Title	Tyrphostin A9 protects axons in experimental autoimmune encephalomyelitis through activation of ERKs

Results of multiple sclerosis :

Result	In the relapsing-remitting EAE model, oral administration of A9 successfully ameliorated clinical symptoms, activated ERK1/2, induced axonal protection, and increased the abundance of the regeneration biomarker GAP-43 in the CNS.
Mechanism/pathway	Activation of ERK1/2 is necessary and sufficient for nerve growth factor (NGF)-induced PC12 cell differentiation [10]. It can protect neurons from apoptosis due to injury or toxicity [11,12,13] and is involved in promoting neuronal survival