Basic information of Tlr2 :

Official Symbol of Gene	Tlr2
Species	Mus musculus
Entrez Gene ID	24088
Official Full Name	toll-like receptor 2
Also known as	Ly105
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000027995 AllianceGenome:MGI:1346060
Map Location	3; 3 E3
Drug	Toll-like receptor 2 and 4 antagonism
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57BL/6J
Disease	experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID	33358978
Year	2022
Title	Toll-like receptor 2 and 4 antagonism for the treatment of experimental autoimmune encephalomyelitis (EAE)-related pain

Results of multiple sclerosis :

Result	The data demonstrated that blocking TLR2/TLR4 suppressed EAE-related pain, equally in males and females; upregulation of dorsal spinal cord proinflammatory gene expression for TLR2, TLR4, NLRP3, interleukin-1β, IkBα, TNF-α and interleukin-17; and upregulation of dorsal spinal cord expression of glial immunoreactivity markers.
Mechanism/pathway	Toll-like receptors 2 and 4 (TLR2/TLR4) have emerged as targets for treating a wide array of autoimmune disorders, including MS, as well as having demonstrated success at suppressing pain in diverse animal models.