Basic information of Il-23 a :
| Official Symbol of Gene | Il-23 a |
| Species | Mus musculus |
| Entrez Gene ID | 83430 |
| Official Full Name | interleukin 23, alpha subunit p19 |
| Also known as | p19; IL-23 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000025383 AllianceGenome:MGI:1932410 |
| Map Location | N/A |
| Drug | RIL-23R |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | C57BL/6J |
| Disease | experimental autoimmune encephalomyelitis |
Literature information of multiple sclerosis :
| Pubmed ID | 35325396 |
| Year | 2022 |
| Title | Genetically Engineered Mesenchymal Stem Cell Therapy Against Murine Experimental Autoimmune Encephalomyelitis |
Results of multiple sclerosis :
| Result | The transfection of RIL-23R mRNA improved MSC properties significantly to the inflamed regions of EAE mice, and it performed an increased suppressive function on the T lymphocyte proliferation |
| Mechanism/pathway | Interleukin 23 (IL-23), which belongs to the interleukin 12 families, plays a vital role in the proliferation of T lymphocytes. Two dif- ferent subunits (specific subunit: IL23A or IL-23p19) and general subunit (IL12Rβ1) are found in the structure of het- erodimer receptors of this cytokine [4]. In addition, Th17 cells secrete IL-17 and IL-23 under the influence of vari- ous factors, including the transforming growth factor-beta (TGF-β) and IL-6. These cytokines lead to Th17 and Th1 cell activation, development of inflammation, and suppres- sion of the immune system |
