Basic information of Gdnf :

Official Symbol of Gene	Gdnf
Species	Rattus norvegicus
Entrez Gene ID	25453
Official Full Name	glial cell derived neurotrophic factor
Also known as	gndf
Gene Type	protein coding
dbXrefs	Ensembl:ENSRNOG00000012819 AllianceGenome:RGD:2677
Map Location	2q16
Drug	GDNF / NSCs
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	N/A
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	27212951
Year	2016
Title	GDNF Enhances Therapeutic Efficiency of Neural Stem Cells-Based Therapy in Chronic Experimental Allergic Encephalomyelitis in Rat

Results of multiple sclerosis :

Result	The rats that received NSCs recovered their normal gait at 50 days after EAE induction, whereas the rats receiving GDNF/NSCs recovered at 45 days after EAE induction.
Mechanism/pathway	In summary, we showed here that GDNF/NSCs grafting significantly promotes functional recovery in EAE rats, reducing brain inflammatory infiltration, improving density of myelin, increasing repopulation of neurons and oligodendrocyte lineage cells, and decreasing the astrocyte differentiation of NSCs.