Basic information of Nr4a2 :

Official Symbol of Gene	Nr4a2
Species	Mus musculus
Entrez Gene ID	18227
Official Full Name	nuclear receptor subfamily 4, group A, member 2
Also known as	NOT; HZF-3; Nurr1; RNR-1; TINOR; TINUR
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000026826 AllianceGenome:MGI:1352456
Map Location	2 C1.1; 2 31.66 Cm
Drug	isoxazolo-pyridinone 7e
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	N/A
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	25265488
Year	2014
Title	Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice

Results of multiple sclerosis :

Result	In the preventive treatment, immunized mice received the compound via gavage beginning from the 7th d.p.i., when phenotypic EAE signs are not yet evident but the immunization process has already occurred. The analysis revealed that the IP7e preventive treatment was able to delay the disease progression.
Mechanism/pathway	A potential mechanism at the basis of the improvement of EAE observed after the preventive IP7e treatment could be represented by the block in the early phase of the disease of the pro-inflammatory NF-kB pathway by Nurr1 signalling activation.