Basic information of Cd44 :

Official Symbol of Gene	Cd44
Species	Mus musculus
Entrez Gene ID	12505
Official Full Name	CD44 antigen
Also known as	Ly-24; Pgp-1; HERMES
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000005087 AllianceGenome:MGI:88338
Map Location	2 E2; 2 54.13 cM
Drug	PH20 hyaluronidase
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	N/A
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	22865853
Year	2012
Title	Hyaluronan Anchored to Activated CD44 on Central Nervous System Vascular Endothelial Cells Promotes Lymphocyte Extravasation in Experimental Autoimmune Encephalomyelitis

Results of multiple sclerosis :

Result	These improved symptoms correspond histologically to degradation of HA in the lumen of CNS blood vessels, decreased demyelination, and impaired CD4(+) T-cell extravasation.
Mechanism/pathway	In conclusion we have demonstrated that standard CD44 on CNS ECs but not activated lymphocytes contributes to lymphocyte rolling on the endothelial surface. These findings expand the knowledge of mechanisms promoting inflammatory demyelinating CNS disease and suggest that HA anchored to EC CD44 represents a therapeutic target to reduce immune cell infiltration into the brain.