Basic information of Pparg :

Official Symbol of Gene	Pparg
Species	Mus musculus
Entrez Gene ID	19016
Official Full Name	peroxisome proliferator activated receptor gamma
Also known as	Nr1c3; PPARgamma; PPAR-gamma; PPARgamma2; PPAR-gamma2
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000000440 AllianceGenome:MGI:97747
Map Location	6 E3; 6 53.41 cM
Drug	PPAR-gamma ligand 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ2)
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	N/A
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	11859145
Year	2002
Title	Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta(12,14)-prostaglandin J(2) ameliorates experimental autoimmune encephalomyelitis

Results of multiple sclerosis :

Result

Administration of 15d-PGJ2 before and at the onset of clinical signs of EAE significantly reduced the severity of disease.

Mechanism/pathway

Initial studies have shown that the presence of the PPAR-gamma ligand 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ2) inhibits the proliferation of Ag-specific T cells from the spleen of myelin basic protein Ac(1-11) TCR-transgenic mice. 15d-PGJ2 suppressed IFN-gamma, IL-10, and IL-4 production by both Con A- and myelin basic protein Ac(1-11) peptide-stimulated lymphocytes as determined by ELISA and ELISPOT assay.