Basic information of Ccl2 :

Official Symbol of Gene	Ccl2
Species	Mus musculus
Entrez Gene ID	20296
Official Full Name	chemokine (C-C motif) ligand 2
Also known as	JE; HC11; MCAF; MCP1; MCP-1; Scya2; Sigje; SMC-CF
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000035385 AllianceGenome:MGI:98259
Map Location	11 B5; 11 49.82 Cm
Drug	P8A-CCL2
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	N/A
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	19232440
Year	2009
Title	Administration of a monomeric CCL2 variant to EAE mice inhibits inflammatory cell recruitment and protects from demyelination and axonal loss

Results of multiple sclerosis :

Result	P8A-CCL2 administration, however, decreased demyelination, axonal loss and number of CNS infiltrating T cells and macrophages.
Mechanism/pathway	Immunological analysis revealed that P8A-CCL2 does not act on Ag-specific T cell proliferation and does not interfere with the differentiation of IFNgamma-releasing effectors T cells. These results suggest that the therapeutic mechanism of P8A-CCL2 may rely on interference with immune cell recruitment.