Basic information of Cx3cr1 :

Official Symbol of Gene	Cx3cr1
Species	Mus musculus
Entrez Gene ID	13051
Official Full Name	chemokine (C-X3-C motif) receptor 1
Also known as	Mcx3cr1
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000052336 AllianceGenome:MGI:1333815
Map Location	9; 9 F4
Drug	TAM
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	N/A
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	33732230
Year	2021
Title	Peroxisome Proliferator-Activated Receptor-δ Deficiency in Microglia Results in Exacerbated Axonal Injury and Tissue Loss in Experimental Autoimmune Encephalomyelitis

Results of multiple sclerosis :

Result	The only difference in this experimental system was that TAM-treated mice exhibited a slight delay in EAE and a trend for reduced clinical scores compared to vehicle-treated mice in the acute phase (Figure 1C), which we found to associate with an unanticipated effect of the TAM in inhibiting myelin-specific Th17 responses and immune cell accumulation in the CNS.
Mechanism/pathway	It is also possible that the escalation in inflammation just occurred as a secondary consequence of the increased myelin and neuronal damage in the CNS of Cx3cr1CreERT2:Ppardfl/fl mice.