Basic information of Ifnb1 :
| Official Symbol of Gene | Ifnb1 |
| Species | Mus musculus |
| Entrez Gene ID | 15977 |
| Official Full Name | interferon beta 1, fibroblast |
| Also known as | Ifb; IFNB; If1da1; IFN-beta |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000048806 AllianceGenome:MGI:107657 |
| Map Location | 4 C4; 4 41.91 Cm |
| Drug | MSCs-IFN β |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | N/A |
| Disease | EAE |
Literature information of multiple sclerosis :
| Pubmed ID | 23710456 |
| Year | 2013 |
| Title | Gene therapy of multiple sclerosis using interferon β-secreting human bone marrow mesenchymal stem cells |
Results of multiple sclerosis :
| Result | Importantly, injected MSCs-IFN β migrated into inflamed CNS and significantly reduced further injury of blood-brain barrier (BBB) permeability in EAE mice. |
| Mechanism/pathway | In conclusion, this study demonstrated that hBM-MSCs can be used as a new delivery vehicle for IFN-β therapy against EAE, and MSCs-IFNβ exhibit strong therapeutic effects by decreasing inflammatory cell influx, suppressing demyelination and immunomodulatory effects by promoting a shift from the Th1 to the Th2 cytokine balance, stabilizing the BBB and preventing the progression of disease in EAE mice. |
