Basic information of Ltbr :

Official Symbol of Gene	Ltbr
Species	Mus musculus
Entrez Gene ID	17000
Official Full Name	lymphotoxin B receptor
Also known as	Ltar; TNFCR; Tnfbr; TNFRrp; LTbetaR; TNFR-RP; Tnfrsf3; TNFR2-RP; TNF-R-III
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000030339 AllianceGenome:MGI:104875
Map Location	6 F3; 6 59.32 Cm
Drug	LTbetaR-Ig
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	RREAE
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	16870269
Year	2006
Title	Suppression of established experimental autoimmune encephalomyelitis and formation of meningeal lymphoid follicles by lymphotoxin beta receptor-Ig fusion protein

Results of multiple sclerosis :

Result	The present findings indicate that both LTbeta and LTbetaR are upregulated at EAE onset and during subsequent relapses and that systemic and local blockade of the LT pathway with LTbetaR-Ig results in protracted and transient inhibition of EAE clinical signs, respectively.
Mechanism/pathway	LTbetaR-Ig treatment also reduces T- and B-cell infiltration and prevents the induction of the chemokines CXCL10 and CXCL13 and the formation of organized ectopic follicles in the EAE-affected CNS.