Basic information of NFE2L2 :

Official Symbol of Gene	NFE2L2
Species	Homo sapiens
Entrez Gene ID	4780
Official Full Name	NFE2 like bZIP transcription factor 2
Also known as	NRF2; HEBP1; Nrf-2; IMDDHH
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000116044 MIM:600492; AllianceGenome:HGNC:7782
Map Location	2q31.2
Drug	dimethyl fumarate
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	N/A
Disease	MS

Literature information of multiple sclerosis :

Pubmed ID	28460056
Year	2017
Title	Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans

Results of multiple sclerosis :

Result	We show here that dimethyl fumarate (DMF) dose-dependently induces mitochondrial biogenesis and function dosed to cells in vitro, and also dosed in vivo to mice and humans.
Mechanism/pathway	Thus, DMF induces mitochondrial biogenesis primarily through its action on Nrf2, and is the first drug demonstrated to increase mitochondrial biogenesis with in vivo human dosing.