Basic information of ABCB1 :

Official Symbol of Gene	ABCB1
Species	Homo sapiens
Entrez Gene ID	5243
Official Full Name	ATP binding cassette subfamily B member 1
Also known as	CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170; p-170
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000085563 MIM:171050; AllianceGenome:HGNC:40
Map Location	7q21.12
Drug	mitoxantrone
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	n=121
Disease	MS

Literature information of multiple sclerosis :

Pubmed ID	19605531
Year	2009
Title	ABC-transporter gene-polymorphisms are potential pharmacogenetic markers for mitoxantrone response in multiple sclerosis

Results of multiple sclerosis :

Result	In conclusion, SNPs in ABC-transporter genes may serve as pharmacogenetic markers associated with clinical response to MX therapy in multiple sclerosis.
Mechanism/pathway	ATP-binding cassette-transporters ABCB1 and ABCG2 represent multi-drug resistance mechanisms involved in active cellular MX efflux.