Basic information of IRF5 :
| Official Symbol of Gene | IRF5 |
| Species | Homo sapiens |
| Entrez Gene ID | 3663 |
| Official Full Name | interferon regulatory factor |
| Also known as | SLEB10 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000128604 MIM:607218; AllianceGenome:HGNC:6120 |
| Map Location | 7q32.1 |
| Drug | IFN-b |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | Peripheral blood |
| Disease | MS |
Literature information of multiple sclerosis :
| Pubmed ID | 20861862 |
| Year | 2010 |
| Title | Validation of IRF5 as multiple sclerosis risk gene: putative role in interferon beta therapy and human herpes virus-6 infection |
Results of multiple sclerosis :
| Result |
The combined analysis of available datasets yielded an effect size on MS with odds ratio (OR)MantelHaenszel |
| Mechanism/pathway | 1 IRF pathways also participate in the regulation of the antiviral innate response.2 IRF5-induced innate antiviral responses appear to result in a broad alteration of the transcriptional profile of cellular genes.3,4 IRF5 is expressed mainly in lymphocytes and dendritic cells, but it is induced in other cells in response to type I interferon (IFN)5 |
