Basic information of IRF5 :

Official Symbol of Gene	IRF5
Species	Homo sapiens
Entrez Gene ID	3663
Official Full Name	interferon regulatory factor
Also known as	SLEB10
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000128604 MIM:607218; AllianceGenome:HGNC:6120
Map Location	7q32.1
Drug	IFNb
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	Peripheral blood
Disease	MS

Literature information of multiple sclerosis :

Pubmed ID	21471993
Year	2011
Title	Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferonb therapy in multiple sclerosis

Results of multiple sclerosis :

Result

We found that patients with the IRF5 rs2004640-TT and rs47281420-AA genotype exerted a poor pharmacological response to IFNb compared with patients carrying the respective G-alleles (P 0.0006 and P 0.0023, respectively). Moreover, patients with the rs2004640-TT genotype developed more magnetic resonance imaging (MRI)-based T2 lesions during IFNb treatment (P 0.003). Accordingly, an association between MRI-based non-responder status and rs2004640-TT genotype was observed (P 0.010). For the rs4728142-AA genotype a trend of an association with more T2 lesions during IFNb treatment and MRI-based non-responder status was observed (P 0.103 and P 0.154, respectively).

Mechanism/pathway

Clinical non-responders were characterized by an increased expression of IFN response genes before the start of therapy, and a lack of a pharmacologically induced increase in IFN response gene activity. Because Interferon Regulatory Factor 5 (IRF5) is a master regulator of IFN-activity, we carried out a candidate gene study of IRF5 gene variants in relation to the pharmacological and clinical response upon IFNb treatment