Basic information of IFNAR1 :
| Official Symbol of Gene | IFNAR1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3454 |
| Official Full Name | interferon alpha and beta receptor subunit 1 |
| Also known as | AVP; IFRC; IFNAR; IFNBR; IMD106; IFN-alpha-REC |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000142166 MIM:107450; AllianceGenome:HGNC:5432 |
| Map Location | 21q22.11 |
| Drug | IFNb |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | CSF |
| Disease | MS |
Literature information of multiple sclerosis :
| Pubmed ID | 24850724 |
| Year | 2014 |
| Title | The Role of Endogenous IFN-b in the Regulation of Th17 Responses in Patients with Relapsing-Remitting Multiple Sclerosis |
Results of multiple sclerosis :
| Result | In vivo recombinant IFN-b–1a treatment induced IFNAR1 and its downstream signaling molecules’ gene expression, suggesting that treatment reconstitutes a deficient endogenous IFN-b regulation of the CD4+ T cells’ pathogenic cytokine production in patients with MS. |
| Mechanism/pathway | We identified that the endogenous IFN-b from serum of RRMS patients induced a significantly lower IFN-inducible gene expression in comparison with healthy controls. In addition, in vitro studies have revealed deficient endogenous and exogenous IFN-b signaling in the CD4+ cells derived from patients with MS. Interestingly, upon inhibition of the endogenous IFN-b signaling by silencing IFN regulatory factor (IRF) 7 gene expression, the resting CD4+ T cells secreted significantly higher level of IL-17A, IL-17F, IL-21, IL-22, and IL-9, suggesting that endogenous IFN-b suppresses the secretion of these pathogenic cytokines. |
