Basic information of TBX21 :
| Official Symbol of Gene | TBX21 |
| Species | Homo sapiens |
| Entrez Gene ID | 30009 |
| Official Full Name | T-box transcription factor 21 |
| Also known as | TBET; IMD88; T-PET; T-bet; TBLYM |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000073861 MIM:604895; AllianceGenome:HGNC:11599 |
| Map Location | 17q21.32 |
| Drug | Silymarin |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | Peripheral blood |
| Disease | MS |
Literature information of multiple sclerosis :
| Pubmed ID | 30178232 |
| Year | 2018 |
| Title |
Immunoregulatory Effects of Silymarin on Proliferation and Activation of Th1 Cells Isolated from Newly Diagnosed and IFN- |
Results of multiple sclerosis :
| Result | IFN-γ level at a concentration of 100 μM in comparison with DMSO. Our findings here clearly show that silymarin is an effective regulator for Th1 response in vitro condition. It not only suppresses Th1 proliferating activity but also inhibits T-bet gene expression and IFN-γ production by these cells |
| Mechanism/pathway | T-bet gene expression was significantly decreased in Th1 cells isolated from newly diagnosed and IFN-β-treated RRMS patients after treatment with silymarin compared to DMSO control. |
