Basic information of Ltbr :

Official Symbol of Gene	Ltbr
Species	Mus musculus
Entrez Gene ID	17000
Official Full Name	lymphotoxin B receptor
Also known as	Ltar; TNFCR; Tnfbr; TNFRrp; LTbetaR; TNFR-RP; Tnfrsf3; TNFR2-RP; TNF-R-III
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000030339 AllianceGenome:MGI:104875
Map Location	6 F3; 6 59.32 cM
Drug	vesnarinone
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	glial cell
Disease	MS

Literature information of multiple sclerosis :

Pubmed ID	10210262
Year	1999
Title	EFFECTS OF VESNARINONE ON CYTOKINE PRODUCTION AND ACTIVATION OF MURINE MICROGLIA

Results of multiple sclerosis :

Result

In the CNS, TNFa is produced by astrocytes and microglia (4). Microglia may be the main producer of TNFIx, because they respond to produce TNFcr much faster than astrocytes and respond to much lower concentration of lipopolysacclharide (LPS) than do astrocytes (4). In this study, we examined the effects ofvesnarinone on TNFa production by microglia. The effects on the other functions of microglia such as proliferation, expression of major histocompatibility complex antigen, enzyme activity and superoxide anion formation were also examined.

Mechanism/pathway

Tumor necrosis factor 01 (TNFcr) is considered to play a critical role in the development of various pathological processes in the central nervous system (CNS), such as neuronal degeneration, demyelination and gliosis. In order to search for agents which suppress TNFcx production in the CNS for future treatment of these pathological conditions, the effects of a synthetic oral inotropic agent, vesnarinone, on murine microglia were examined. Vesnarinone significantly suppressed TNFa production by microglia in a dose-dependent manner, without affecting their viability, enzyme activity or expression of the major histocompatibility complex.