Basic information of CD40 :
| Official Symbol of Gene | CD40 |
| Species | Homo sapiens |
| Entrez Gene ID | 958 |
| Official Full Name | CD40 molecule |
| Also known as | p50; Bp50; CDW40; TNFRSF5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000101017 MIM:109535; AllianceGenome:HGNC:11919 |
| Map Location | 20q13.12 |
| Drug | IFN |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | peripheral blood |
| Disease | MS |
Literature information of multiple sclerosis :
| Pubmed ID | 11830590 |
| Year | 2002 |
| Title | Critical Role of Tumor Necrosis Factor-a and NF-B in Interferon-+-induced CD40 Expression in Microglia/Macrophages |
Results of multiple sclerosis :
| Result | IFN-r treatment leads to the activation of NF-B in a time-dependent manner, which is inhibited in the presence of anti-TNF-β-neutralizing antibody. These results indicate that IFN-+-induced TNF-β production and subsequent NF-B activation are integral parts of the mechanism of IFN-+-induced CD40 expression |
| Mechanism/pathway | we have discovered that a major component of IFN-r-induced CD40 expression involves the endogenous production of the cytokine TNF-r. The inclusion of anti-TNF-r-neutralizing antibody significantly inhibits IFN-r-induced CD40 mRNA and CD40 promoter activity. IFN-r-induced CD40 protein expression is attenuated in TNF-r-deficient microglia and can be restored with exogenous TNF-r. Sitedirected mutagenesis studies demonstrate that three of the four NF-B elements in the CD40 promoter are required for IFN-r-induced CD40 promoter activity |
