Basic information of Rtn4 :
| Official Symbol of Gene | Rtn4 |
| Species | Mus musculus |
| Entrez Gene ID | 68585 |
| Official Full Name | reticulon 4 |
| Also known as | ASY; NgA; NOGO; NSP-CL; Nogo-A; Nogo-B; Nogo-C; mKIAA0886; mKIAA4153; 1110020G17Rik; C130026I10Rik |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000020458 AllianceGenome:MGI:1915835 |
| Map Location | 11; 11 A3.3 |
| Drug | curcumin |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | spinal cord |
| Disease | MS |
Literature information of multiple sclerosis :
| Pubmed ID | 33953873 |
| Year | 2019 |
| Title | Molecular effects of curcumin on the experimental autoimmune encephalomyelitis |
Results of multiple sclerosis :
| Result | The obtained results indicated it could be concluded that curcumin was able to improve EAE by increasing the amount of MBP gene expression and reducing the intensity of NOGO-A expression |
| Mechanism/pathway | Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS). Previous studies have shown that myelin degradation during MS and EAE resulted in reduced expression of some of the proteins, e.g., the MBP (myelin basic protein), and increased expression of genes such as iNOS (Inducible nitric oxide synthase) and NOGO-A in the affected patients. In the present study, EAE was induced by immunizing Wistar rats (n=12) with homogenized spinal cord of guinea pig and Freund's complete adjuvant. |
