Basic information of Nfe2l2 :

Official Symbol of Gene	Nfe2l2
Species	Mus musculus
Entrez Gene ID	18024
Official Full Name	nuclear factor, erythroid derived 2, like 2
Also known as	Nrf2
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000015839 AllianceGenome:MGI:108420
Map Location	2 C3; 2 44.75 cM
Drug	Tecfidera
Interaction Type	activor

Sample information of multiple sclerosis:

Descent	C57BL/6J mice
Disease	MS

Literature information of multiple sclerosis :

Pubmed ID	31362266
Year	2021
Title	Monomethylfumarate Protects against Ovariectomy-related Changes in Body Composition

Results of multiple sclerosis :

Result	our results suggested that MMF could potentially be used as a drug to minimize bone loss as a promising alternative to oral antioxidants. MMF activates endogenous antoxidant pathways like HO-1 and Nrf2, which allow the body to modulate levels of ROS with innate gene regulation and protein localization
Mechanism/pathway	The multiple sclerosis drug Tecfidera contains dimethylfumarate, which is rapidly metabolized to monomethylfumarate (MMF); MMF is thought to function through nuclear factor erythroid-derived-2-like-2 (Nrf2), a transcription factor activated by oxidative stress which induces the expression of endogenous antioxidant systems.