Basic information of Tnf :
| Official Symbol of Gene | Tnf |
| Species | Mus musculus |
| Entrez Gene ID | 21926 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; Tnfa; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000024401 AllianceGenome:MGI:104798 |
| Map Location | 17 B1; 17 18.59 cM |
| Drug | Ketamine |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | Male BALB/c mice |
| Disease | ischemic or traumatic brain injury |
Literature information of multiple sclerosis :
| Pubmed ID | 11032280 |
| Year | 2000 |
| Title | Ketamine suppresses endotoxin-induced NF-6B expression |
Results of multiple sclerosis :
| Result | Ketamine inhibits endotoxin-induced NF-6B expression in brain cells in vivo and vitro and it is suggested that this may have implications in the neuroprotective effects of ketamine reported by other investigators |
| Mechanism/pathway | Ketamine suppressed endotoxin-induced neuronal NF-6B activation in a dose-dependent manner (P < 0.05, except for the 10–5M concentration in vitro) both in vivo and vitro |
