Basic information of Hdac1 :
| Official Symbol of Gene | Hdac1 |
| Species | Mus musculus |
| Entrez Gene ID | 433759 |
| Official Full Name | histone deacetylase 1 |
| Also known as | HD1; RPD3; MommeD5; Hdac1-ps |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000028800 AllianceGenome:MGI:108086 |
| Map Location | 4 D2.2; 4 63.26 cM |
| Drug | FTY720-Phosphate |
| Interaction Type | activor |
Sample information of multiple sclerosis:
| Descent | LM/Bc mice |
| Disease | MS |
Literature information of multiple sclerosis :
| Pubmed ID | 26719367 |
| Year | 2016 |
| Title | Elevated Nuclear and Cytoplasmic FTY720-Phosphate in Mouse Embryonic Fibroblasts Suggests the Potential for Multiple Mechanisms in FTY720-Induced Neural Tube Defects |
Results of multiple sclerosis :
| Result | Elevated nuclear FTY720-P is associated with decreased HDAC activity and increased histone acetylation at H3K18 and H3K23 in LM/Bc MEFs. Treatment of LM/Bc MEFs with FTY720 and a selective Sphk2 inhibitor, ABC294640, significantly reduces the amount of FTY720-P that accumulates in the nucleus. The data provide insight into the relative amounts of FTY720-P generated in the nuclear versus cytoplasmic subcellular compartments after FTY720 treatment and the specific Sphk isoforms involved |
| Mechanism/pathway | The results of this study suggest that FTY720-induced NTDs may involve multiple mechanisms, including: (1) sustained and/or altered S1P receptor activation and signaling by FTY720-P produced in the cytoplasm and (2) HDAC inhibition and histone hyperacetylation by FTY720-P generated in the nucleus that could lead to epigenetic changes in gene regulation |
