Basic information of Nos2 :
| Official Symbol of Gene | Nos2 |
| Species | Mus musculus |
| Entrez Gene ID | 18126 |
| Official Full Name | nitric oxide synthase 2, inducible |
| Also known as | iNOS; Nos-2; Nos2a; i-NOS; NOS-II; MAC-NOS |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000020826 AllianceGenome:MGI:97361 |
| Map Location | 11 B5; 11 46.74 cM |
| Drug | LX007 |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | C57/BL6J |
| Disease | MS |
Literature information of multiple sclerosis :
| Pubmed ID | 29198015 |
| Year | 2017 |
| Title | The Anti-inflammatory Effects of 4-((5-Bromo-3-chloro2-hydroxybenzyl) amino)-2-hydroxybenzoic Acid in Lipopolysaccharide-Activated Primary Microglial Cells |
Results of multiple sclerosis :
| Result | We therefore conclude that LX007 exhibits anti-inflammatory effects in LPS-stimulated microglial cells by inhibiting pro-inflammatory mediators corresponding to the downregulating of MAPKs and NF-κB activation. Taken together, the present study indicated that LX007 may have potential to be developed into an anti-inflammatory agent in the future. |
| Mechanism/pathway | LX007 inhibited lipopolysaccharide (LPS)-stimulated nitric oxide (NO) and prostaglandin E2 (PGE2) expression, as well as their regulatory geneinducible NO syntheses (iNOS) and cyclooxygenase-2 (COX-2) in LPS-treated primary microglia. LPS-induced production from microglia of interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF-α) was also significantly attenuated by LX007. Mechanistically, LX007 potently suppressed phosphorylation of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-κB) p65 nuclear translocation in LPS-induced microglia. |
