Basic information of RORC :

Official Symbol of Gene	RORC
Species	Homo sapiens
Entrez Gene ID	6097
Official Full Name	RAR related orphan receptor C
Also known as	TOR; RORG; RZRG; IMD42; NR1F3; RZR-GAMMA
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000143365 MIM:602943; AllianceGenome:HGNC:10260
Map Location	1q21.3
Drug	IFN-b-1a
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	N/A
Disease	MS

Literature information of multiple sclerosis :

Pubmed ID	26601116
Year	2015
Title	Immunologic and MRI markers of the therapeutic effect of IFN-b-1a in relapsing-remitting MS

Results of multiple sclerosis :

Result	Findings indicate that IFN-b-1a suppresses Th22 and Th17 cell responses, which were associated with decreased MRI-detectable demyelination
Mechanism/pathway	IFN-b-1a induced reductions in transcription factor AHR, T-bet, and retinoic acid–related orphan nuclear hormone receptor C (RORc) gene expression, while it increased GATA3’s expression in CD41 cells